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Yyyyyy x. yyyyyy

0000 xxxxxx xxxx , xxxx , xxxxx 00000

                                                                                                                                           xxx-xxx-xxxx

Abc@xyz.com

 

Senior Chemist / Researcher

Project Management ~ Drug & Therapeutic Development

 

Results-driven and versatile Researcher and Chemistry SME seeking a new application of specialized skill set including R&D, Support and Development, and Quality Assurance as well as comprehensive Data Analysis.  Eager to apply these skills to an organization in need of an extremely organized and independent professional astute at streamlining processes and implementing efficiency best practices to increase productivity of research methodologies.

  Chemical Analysis

  Report Development

  Lateral Thinking

  Research & Development

  Quality Assurance

  Technology Savvy

  Chemical Processes

  Qualitative Research Analysis

  Regulatory Compliance

 

Qualifications Profile

 

Ø  Strong multi-tasking background with the ability to work independently on multiple projects simultaneously, including advanced research, project management, in-depth analysis, operational process implementation, as well as development and execution of strategies to increase efficacy of funds and research. 

Ø  Possesses strong organizational and analytical skills.

Ø  Highly adaptable in quickly changing technical environments.

Ø  Effectively strategizes with management team and resolves complex organizational issues. 

Ø  Excel in defining and implementing policies, procedures and operational systems that boost productivity, efficiency and quality of operations.

Ø  Consistently focus on ensuring development of high-standard delivery methodologies. 

Ø  Proven ability to adapt strong technical skills to diverse organization needs.

Ø  Skilled at communicating cross-functionally in order to ensure knowledge sharing is prevalent between departmental lines.

Ø  Embraces corporate culture and actively promotes and leads company initiatives.

Ø  Technology savvy with knowledge of multiple software applications and platforms.  

 

Functional Competencies

 

Ø  Analyze, model and re-engineer various complex processes. 

Ø  Redesigns existing operating procedures by analyzing and identifying areas for improvement.

Ø  Approach problems from a reductionist standpoint and breaks down to find solutions.

Ø  Manage and direct diverse teams in a cross-functional manner to ensure information sharing and resource collaboration. 

Ø  Demonstrate dynamic leadership qualities and strong communication skills in successfully steering planning meetings and delivering comprehensive strategies.

Ø  Develop expert plans of action according to specific needs, both expeditiously and effectively.

Ø  Effectively manage and support staff relevant to specific projects in order to complete assignments on time and on budget.

Ø  Regularly schedule reviews and tracks progress of particular projects.

Ø  Provide project leadership in order to achieve maximum production, including budget control, production timetable, status reporting, client/project team coordination, and quality assurance. 

 

Academic Training

 

n Ph.D. C Organic Chemistry, Indian Institute of Science

n M.S. C Organic and Industrial Chemistry, RKM Vivekananda College

n ACS Short Course C  Computational Chemistry and Computer Assisted Drug Design

n Short Course C Principles of Database Searching

Select Accomplishments

 

n Drug development: Experience in synthesis, analysis of raw material and formulation, stability study and manufacturing of small molecule drugs, specialty chemicals, Aroma and Flavor chemicals

n Therapeutic development: Led project teams charged with the development of synthesis and analysis of existing and innovative therapeutic drugs. Orchestrated manufacturing process development and technology transfer from bench-top scales through large laboratory preparations into pilot and manufacturing facilities. In doing so, wrote raw material specifications, batch records, product specifications, test methods and related validation summaries.

n Project management: Developed and executed both short- and long-range plans that integrated efforts across project teams and were effective in meeting goals. Recruits and hires the right people and then delegates responsibilities in a way that empowers them to execute in parallel with other team members. Persistently conveys a sense of urgency and drives for results and success within project time lines.

n Technical writing & presentations: Solid record of publications and presentations that attests outstanding ability to complete research in an area, organize the data and material, and convey the information in an interesting, intelligible manner.

n Technology assessment: Participated in teams assessing the state of the art and break-through technologies in materials, drug delivery, new therapies, new diagnostics, etc.

 

Professional Career Track

 

Aug 07 - Present       Boehringer-Ingelheim Pharmaceutical, Ridgefield, CT       

                                              

2006 C 2007              Affiliate, Department of Radiology, DUKE University Medical Center, Durham, NC      

          

2005 C 2007              Self Start-up, Diagnosis (MRI) & Targeting (HT/Chemo) for Cancer, RTP, NC 

                                          

2003 C 2005               Director, Med & Process Chemistry, BioLink Life Sciences, Inc., Cary, NC  

                                          

2002 C 2003              PI, Process Chemistry, DarPharma, Inc., 215 Cloister Ct, Chapel Hill, NC 

                             

2001 C 2002               Postdoctoral Fellow, Expt. Therapeutics, M.D. Anderson Cancer Center, Houston

       

1999 C 2001               Postdoctoral Fellow, Dept. of Chemistry & Biochemistry, Univ. of Texas at Austin           

1998 C 1999               Postdoctoral Fellow, Dept. of Chemistry, Univ. of North Texas, Denton, TX

                    

1997 C 1998              Associate Researcher, CNRS, Centre d Etudes Pharmaceutiques, Paris, France

                    

1988 C 1997               Scientist, Process Chemistry, IDL Industries Ltd, (Currently Astra-Zeneca) Bangalore

                                                                             

1985 C 1988              Chemist, Smith Kline and French Pharmaceuticals (Currently GSK), Bangalore

 

Technology Skills

 

n Database searching using SciFinder Scholar, Beilstein Crossfire, Thomson Pharma, CAS, Nerac, Compendex, CHEMnetBASE, PubMed, PubChem, CSA, Web of Science, etc;

n Technical Report and Presentation Preparation using Microsoft Word, Excel, and Powerpoint, Chemdraw Pro, Chem 3D Modeling Software

n Experience in Sybyl/Biopolymer Molecular Modeling (Visualize Molecules, Conformation Search, Unity Flex Search, and Pharmacophore Mapping)

 

Professional Affiliations, Awards & Funding

 

n Member, American Chemical Society & ACS Organic Division

n IDL Industries Limited awarded & sponsored Ph.D. Program with Indian Institute of Science, Bangalore under Work-Study program

n CNRS Fellow Award

n Novel Pro-Dyes to expand use of the VerifEye Contamination Detection System C USDA $80,000 Awarded

Specialized Skills Description

 

 

Chemical Process Development

 

  • Chemical Process Development for API, Aroma Chemicals and Specialty Chemicals.
  • Conducted Multi-step Synthesis from Milligram to Kilogram quantities
  • Process feasibility studies, lab/pilot scale modeling, cost/benefit analyses, project planning & implementation
  • Isolation, characterization and synthesis of impurities and analytical markers
  • Process optimization, qualification of alternate raw materials,  transfer of technology from development to production
  • Effluent treatment and Risk Assessment
  • Excellent laboratory skills and knowledge of organic synthesis and Ph.D. in Organic Chemistry

 

Medicinal chemistry -Drug Discovery - SAR studies -Small Molecule Synthesis 

 

  • Design and synthesis of Biologically active molecules
  • Glucuronide,  Metabolite synthesis for DMPK studies
  • Structure-based design and characterization of novel platforms for Ricin and Shiga toxin inhibition (Heterocyclic chemistry)
  • Inhibition of human telomerase by 7-deaza-2'-deoxyguanosine nucleoside triphosphate analogs: Potent inhibition by 6-thio-7-deaza-2'-deoxyguanosine 5'-triphosphate (Nucleotide and Nucleoside Chemistry),
  • Synthesis of Nitrones, PI3 Kinase Inhibitors (Inositol Chemistry), Trifluoromethyl Analog of Kainic Acid (Fluorine bioorganic chemistry)
  • Mechanism and Metabolized based drug design and synthesis
  • Synthesis of NLS and cRGDf K Peptides and its Conjugate for drug transport

 

Metabolite & Radiation labeling

 

  • Glucuronide, Acyl glucuronide synthesis
  • Synthesis of Radiation Labeling (131I, 125I, 18F, 211At & 14C)  compounds
  • Synthesis of stabilized Isotope (2H, 13C) molecules

 

Nanomaterials

 

  • Synthesis of Iron and Gold nanoparticles
  • Encapsulation of Nanoparticles
  • Bioconjugation of Nanomaterials
  • Nanogels

 

 

Analytical Chemistry C Instrumentation C Formulation C Stability

 

  • Analytical Method Development, Drug Monitoring, Method Validation and Stability Testing  for pharmaceutical formulations and its raw materials
  • Performs U.S.P. dissolution testing of solid dosage forms for evaluation of functional (extended release) and non-functional (immediate release) film coatings.
  • Performs analytical testing of various departmental powder, tablet, or liquid samples according to USP, BP and IP
  • Provides project status updates in a concise and timely manner
  • Provides trouble shooting for methods development
  • Acquisition and analysis of FT-NMR (1H, 13C, APT, DEPT and 19F), FT-IR, GC, GC-MS, HPLC, GPC/GFC, UV-Vis, polarimeter, DSC, TGA, Dynamic Light Scattering for measuring Nanoparticle dimensions, Scintillation counter.
  • Analysis of Polymer Reagents and its Conjugates

 

 

 

 

 

 

 

 

New Material C Technology Development C Trouble Shooting

 

  • Developed a Biodegradable Polymer for binding to Silica chips, Glass and Nobel Metal surfaces.
  • Developed a  MAGNAGEL (Iron Nanoparticle containing Hydrogel), for Magnetic Resonance Imaging (MRI)
  • Discovery and Development of Novel Conjugates (Biotin / Drug / Peptide / Dye / Protein Conjugate)
  • Developed a  Reagents which form insitu Hydrogel to fill a synthetic graft tube, a Cardiovascular Medical Device, for treatment of an Aortic Aneurysm
  • Design and synthesis of  stable & high soluble Anti-Oxidant C Lipoic acid
  • Engineered the light sensitive lipophilic Drug for its increase in Stability & solubility
  • Design and synthesis of Novel Pro-dyes to expand use of the verifEYE contamination Detection System for the automated inspection of each beef carcass
  • PerfluoroReagent and solvent
  • High Energetic Material for Fuel
  • Reagent for Isolation of Metals from the Nuclear Waste
  • Nanoshells containing Gold-Fe Nanoparticle  as Magnetic Resonance Imaging agent

 

Methodology C New Reagents C Fluorous solvents - Functional Group Transformations

 

  • Titanium reagents for functional group transformations
  • Study of Perfluoro & Fluorous Reagent and the Use of Fluorous Phase in Oxidation Reaction
  • Synthesis of Trifluoromethyl Analog of Kainic acid
  • Perfluoro reagent for Green Chemistry
  • Synthesis of Cage containing high energetic molecule
  • Synthesis and Characterization of Macrocyclic crown ether, cryptand for extraction of Li, Na, K and transition metals from Nuclear Waste

 

Polyethylene Glycol Reagents C Reagents for Nanoparticles, Silica, Hydrogel and New Materials

 

  • Synthesis of mPEG-X  (X = Cl, Br, OTs, OMs, OTf, SH, COOH, Amine, Siloxane, Biotin, Lipoate, Maleimide, Acrylate, Acrylamide)
  • Synthesis of Homo and Hetero PEG reagents - Conversion of HO-PEG-OH to X-PEG-Y  (X = Y or X   Y)
  • 3-arms, 4-arms, 5-arms, 6-arms & 8-arms PEG Reagents
  • Bioavailability and stability

 

 

 

 

 

 

 

 

 

 

 

 

 

Publications

 

 

1.   Ravikumar KS, Kesavan V, Crousse B, Bonnet-Delpon D, Begue, JP Mild and Selective Oxidation of Sulfur compounds in Trifluoroethanol: Diphenyl Disulfide and Methyl Phenyl Sulfoxide Organic Syntheses, 2003, 80, 184-189

2.   Ravikumar KS, Farquhar D. Facile selective cleavage of a myo-inositol trans-isopropylidene acetal in the presence of a cis-isopropylidene acetal. Tetrahedron Letters,  2002, 43 (8), 1367-1368

3.   Miller DJ, Ravikumar K, Shen H, Suh JK, Kerwin SM, Robertus JD Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition Journal of Medicinal Chemistry, 2002, 45 (1): 90-98

4.   Fletcher TM, Cathers BE, Ravikumar KS, Mamiya BM, Kerwin SM.  Inhibition of human telomerase by 7-deaza-2 '-deoxyguanosine nucleoside triphosphate analogs: Potent inhibition by 6-thio-7-deaza-2 '-deoxyguanosine 5 '-triphosphate  Bioorganic Chemistry, 2001, 29 (1),36-55

5.   Ravikumar KS, Kesavan V, Bonnet-Delpon D, Begue JP Fluorous solvents in oxidation reactions. Abstracts of papers of the American Chemical Society, 220: U413-U413 3-IEC Part 1, AUG 20 2000

6.   Begue JP, Bonnet-Delpon D, Chennoufi A, Ourevitch M, Ravikumar KS, Rock MH. Highly selective 1,3-dipolar cycloaddition of a cyclic azomethine ylide to ethyltrifluorocrotonates  Journal of  Fluorine Chemistry,  2001, 107 (2), 275-279

7.   Kerwin SM, Ravikumar KS, Miller D, Robertus J  Structure-based design of ricin inhibitors. Abstracts of papers of the American Chemical Society 219: U54-U54 291-MEDI Part 2, MAR 26 2000

8.   Ravikumar KS, Begue JP, Bonnet-Delpon D, Ourevitch M Synthesis in fluorous phase: a convenient synthesis of isolongifolene epoxide and its rearrangement to ketone.   Journal of Fluorine Chemistry, 2000, 102 (1-2), 51-53

9.   Marchand AP, Chong HS, McKim AS, Krishnudu K, Ravikumar KS, Kumar VS, Takhi M, Moyer BA, Chambliss CK, Bryan JC Cage-functionalized, nitrogen-containing macrocycles and podands: Potential new host systems for extraction of NaOH from wastes.  Abstracts of papers of the American Chemical Society 218: U1059-U1059 108-NUCL Part 1, AUG 22 1999

10. Ravikumar KS, Sinha S, Chandrasekaran S Diastereoselectivity in the reduction of acyclic carbonyl compounds with diisopropoxytitanium(III) tetrahydroborate Journal of Organic Chemistry, 1999, 64 (16), 5841-5844

11. Ravikumar KS, Barbier F, Begue JP, Bonnet-Delpon D Selective oxidation of sulfides: selective preparation of 1-trifluoromethyl vinyl sulfoxides Journal of Fluorine Chemistry, 1999,  95 (1-2), 123-125

12. Ravikumar KS, Zhang YM, Begue JP, Bonnet-Delpon D Role of hexafluoro-2-propanol in selective oxidation of sulfide to sulfoxide: Efficient preparation of glycosyl sulfoxides European Journal of Organic Chemistry, 1998, (12), 2937-2940

13. Ravikumar KS, Barbier F, Begue JP, Bonnet-Delpon D Manganese (III) acetate dihydrate catalyzed aerobic epoxidation of unfunctionalized olefins in fluorous solvents.  Tetrahedron, 1998, 54 (26), 7457-7464

14. Ravikumar KS, Begue JP, Bonnet-Delpon D A selective conversion of sulfide to sulfoxide in hexafluoro-2-propanol Tetrahedron Letters, 1998, 39 (20), 3141-3144

15. Ravikumar KS, Chandrasekaran S An unusual reaction of cyclic enol ethers with titanium(III) tetrahydroborate  Tetrahedron, 1997, 53 (8), 2973-2978

16. Ravikumar KS, Chandrasekaran S Chemo- and stereoselective reduction of alpha,beta-epoxyketones with diisopropoxytitanium(III) tetrahydroborate Tetrahedron 1996, 52 (27), 9137-9142

17. Ravikumar KS, Chandrasekaran S Reaction of diisopropoxytitanium(III) tetrahydroborate with selected organic compounds containing representative functional groups  Journal of Organic Chemistry, 1996, 61 (3), 826-830

18. Ravikumar KS, Chandrasekaran S Highly Chemoselective Reduction of 2,5-dinitro-1,4:3,6-dianhydro-D-glucitol with titanium(III) tetrahydroborates C Efficient synthesis of isomerically pure 2-nitro-1,4:3,6-dianhydro-D-glucitol and 5-nitro-1,4:3,6-dianhydro-D-glucitol  Syntheses, 1994, (10), 1032-1034

19. Ravikumar KS, Chandrasekaran S Diisopropoxytitanium(III) tetrahydroborate C A highly useful reagent for the remarkably selective 1,2-reduction of alpha, beta-unsaturated carbonyl compounds  Journal of Organic Chemistry, 1993, 58 (22), 5981-5982

20. Reddy, GO, Ravikumar KS Thermal studies on the decomposition of 3,5-dinitrobenzoic acid and lead salts of  3,5-dinitrobenzoic acid Thermochimica Acta,  1992, 198 (1), 147-165

 

 

 

Ravikumar Seetharama

 

DATE

NAME HERE OF RECIPIENT

NAME HERE OF COMPANY

 

Dear RECIPEINT NAME:

Recent research into COMPANY NAME prompted me to immediately update my resume for your review.   Based on my knowledge of this company, I am very interested in interviewing for STATE POSITION YOU ARE SEEKING. I offer years of progressive advancement in key roles as a Senior Chemist and Researcher.

 I am skilled at providing expertise regarding comprehensive tasks including research and development, chemical analysis, efficiency and productivity protocols and a strong background in all aspects of team collaboration and information sharing.  I am astute at developing streamlined processes that will increase operational productivity and reduce the occurrence of costly errors. 

            I am an exceptionally hard worker and my peers consider me a strong team player.  My enthusiasm comes from working directly with clients and streamlining and improving processes as evidenced by my accomplishments and contributions to my past employers.  I am also capable of assimilating into a new environment easily and feel that I could quickly become part of your team.  I enjoy the chance to work directly with various departmental resources in both learning and mentoring fashions. I am selectively seeking a company who is progressive thinking and in need of a professional who can make an immediate and positive impact on productivity and processes.

            After your review of my resume, I hope you will agree that this would be a mutually beneficial arrangement.  I plan to call you early next week. At that time, I can answer questions concerning my background and experience and we can discuss the desirability of an introductory meeting.  Please contact me sooner if you wish to talk before then.  I look forward to speaking with you.

Sincerely,

Ravikumar Seetharama

                                   

 

 

 

 

 

 

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