scientist/researcher eager to contribute expertise in process chromatography development
toward actively supporting an innovative pharmaceutical/biopharmaceutical organization in optimizing small/large molecule purifications
areas of expertise ~
preparative and analytical methods development, preparative chromatography, simulated moving bed chromatography, chiral isolations, active pharmaceutical compounds purification, process development, technology transfer, manufacturing process demonstration, chromatography scale-up process demonstration, process chromatography simulation, process monitoring, pilot plant equipment cleaning verifications, new technology assessment, project management, preparative chromatography quality by design activities, laboratory quality assurance, employee training
technical proficiencies ~
hplc, parallel column screenings, reverse phase hplc, normal phase hplc, chiral hplc, preparative lc, simulated moving bed chromatography, lc, gc, trace impurity isolations, imprinted stationary phases synthesis, preparative chromatography process simulation, hplc down stream processing, sample enrichments for trace impurity isolations, small molecules purifications, chiral isolations
key achievements/awards ~
gsk bronze impact award; for successful pilot plant campaign for 20kg chiral isolations; 2007
gsk bronze impact award; for demonstrating sense of urgency for the isolation of several impurities to support impurity mapping activities; 2007
gsk bronze impact award; for a low level impurity isolation which provided the project team the mean to identify/characterize and to understand the pathway of the impurity to put the specification on a starting material; 2006
extensive body of publications and presentations
postdoctoral research associate, university of tennessee/oak ridge national laboratory; 2006
ph.d., polymer chemistry, louisiana state university, baton rouge, la; 2004
m.s.eng., polymer engineering, university of akron, akron, oh; 1997
b. eng., textile (polymer) engineering, pusan national university, pusan, south korea; 1995
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glaxosmithkline king of prussia, pa 2006-current
preparative chromatography and pilot plant analyst, analytical science, chemical development
facilitate development and implementation of simulated moving bed chromatography for chiral isolations of drug candidates for early phase projects as well as strategic scale-up process; execute effective approaches for obtaining operating parameters.
efficiently lead pilot plant development and deployment of preparative batch chromatography for kg scales of the purification of small molecule intermediates.
proficiently lead gmp functions including cleaning strategy for preparative instruments and chiral stationary phases.
strategically develop and optimize analytical and preparative lc methods as well as trace impurity isolations sample preparation and hplc downstream processing steps.
effectively use hplc interfaced with empower to deliver quality analytical supports for in-progress- monitoring and cleaning verification activities within pilot plant setting.
conduct thorough column screening for analytical and preparative method development via normal, chiral and reverse phase hplc, steer development of hplc instruments computer interfaces and create, develop and maintain column inventory database.
contribute expertise toward providing comprehensive support of diverse pilot plant production projects targeting chiral and achiral purifications for active pharmaceutical compounds within stringent timelines.
actively collaborate in hplc methods technology transfer functions in support of pilot plant production of drug intermediates.
proficiently create effective working directions for pilot plant campaigns and participate in preparing equipment operating procedures.
facilitate proactive communications across synthetic science, analytical science and process technology departments to maximize pilot plant support of preparative chromatography purifications.
demonstrate dynamic leadership skills in effectively training new staff in preparative chromatography separation analytical techniques and related activities.
oak ridge national laboratories - oak ridge, tn 9/2005-12/2005
post doctoral research associate
successfully investigated inorganic-polymeric hierarchically imprinted materials for applications in separations and chemical sensors.
university of tennessee - knoxville, tn 3/2004-9/2005
post doctoral research associate
effectively modeled thermodynamics and kinetic proprieties of overloaded chromatography.
spearheaded investigations in areas ranging from effects of temperature on retention mechanisms on reverse phase liquid chromatography and monolithic polymeric columns for thermodynamic and mass transfer properties to solvent effect on adsorption and kinetic mechanisms of imprinted polymeric columns and mechanism of chiral separations on imprinted polymeric columns.
proficiently synthesized imprinted polymeric materials for selective recognition of amino acid derivatives.
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1. kim, h.; spivak, d.a. "new insight into modeling non-covalently imprinted polymers" j. am. chem. soc. 2003, 125(37), 11269-11275.
2. kim, h.; spivak, d.a. an orthogonal approach to multifunctional molecularly imprinted polymers org. lett. 2003, 5(19), 3415-3418.
3. kim, h.; gritti, f.; guiochon, g. effect of the temperature on the isotherm parameters of phenol in reverse-phase liquid chromatography j. chromatogr. a. 2004, 1049, 25-36.
4. kim, h.; guiochon, g. comparison of the thermodynamic properties of particulate and monolithic columns of molecularly imprinted polymers anal. chem. 2005, 77, 93-102.
5. kim, h.; guiochon, g. thermodynamic studies on the solvent effects in chromatography on molecularly imprinted polymers. 1. nature of the organic modifier anal. chem. 2005, 77, 1709-1717.
6. kim, h.; guiochon, g. thermodynamic studies on the solvent effects in molecularly imprinted polymers. 2. the concentration of organic modifier anal. chem. 2005, 77, 1718-1726.
7. kim, h.; guiochon, g. thermodynamic studies on the solvent effects in molecularly imprinted polymers. 3. nature of organic mobile phase anal. chem. 2005, 77, 2496-2504.
8. kim, h.; kaczmarski, k.; guiochon, g. mass transfer kinetics on heterogeneous binding sites of molecularly imprinted polymers chem. eng. sci. 2005, 60, 5425-5444.
9. kim, h.; guiochon, g. adsorption on molecularly imprinted polymers of structural analogues of a template. single component adsorption isotherm data anal. chem. 2005, 77, 6415-6425.
10. kim, h.; kaczmarski, k.; guiochon, g. intraparticle mass transfer kinetics on molecularly imprinted polymers of structural analogues of a template chem. eng. sci. 2006, 61, 1122-1137.
11. kim, h.; guiochon, g. thermodynamic functions and intraparticle mass transfer kinetics of structural analogues of a template on molecularly imprinted polymers j. chromatogr. a. 2005, 1097, 84-97.
12. kim, h.; guiochon, g. thermodynamic analysis on heterogenous binding sites of molecularly imprinted polymers j. chromatogr. a. 2006, 1101, 136-152.
13. kim, h.; kaczmarski, k.; guiochon, g. isotherm parameters and intraparticle mass transfer kinetics on molecularly imprinted polymers in acetonitrile/buffer mobile phases chem. eng. sci. 2006, 61, 5249-5267.
14. kim, h.; liang, c.; dai, s. hierarchically imprinted adsorbents in press.
1. spivak, david a.; kim, hyunjung. influence of template-monomer ratio on binding sites within molecular imprinted polymers. polymer preprints (american chemical society, division of polymer chemistry) 2003, 44(1), 661-662.
2. kim, hyunjung; guiochon, georges. thermodynamics and mass transfer kinetics in molecularly imprinted polymers. polymer preprints (american chemical society, division of polymer chemistry) 2005, 46(2), 1178-1179.
3. coauthor, three gsk internal publications.
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1. kim, h.; spivak, d.a. "influence of template-monomer ratio on binding sites within molecular imprinted polymers", march, 2003, 225th acs national meeting, poly-714, new orleans, la.
2. kim, h.; guiochon, g. "solvent effects in molecularly imprinted polymers", february, 2005, pittcon meeting, session 2090-liquid chromatography: detection and high temperature techniques.
1. kim, hyunjung; guiochon, georges. aei: thermodynamics and mass transfer kinetics in molecularly imprinted polymers. abstracts of papers, 230th acs national meeting, washington, dc, united states, aug. 28-sept. 1, 2005, poly-577.
2. kim, hyunjung; guiochon, georges. thermodynamics and mass transfer kinetics in molecularly imprinted polymers. abstracts of papers, 230th acs national meeting, washington, dc, united states, aug. 28-sept. 1, 2005, aei-129.
3, kim, hyunjung. trace impurity isolations by preparative chromatography. as-2008 symposium at gsk, upper providence, pn, united states, june 9, 2008
i would like to thank you for providing me the opportunity to interview with you and discuss the exciting (title of position applying for) position currently available with your company. having gained a deeper insight into the job requirements and your objectives, i am confident you will find me a valuable asset in achieving your goals.
as discussed, i am an enthusiastic, disciplined team player eager to launch a successful career as a dedicated member of your staff. i believe you will find my dynamic (list a few skills/qualifications relevant to the position) skills vital to your operations and look forward to contributing to your success.
should you have any additional questions, or to discuss future employment opportunities, please feel free to contact me at your earliest convenience. again, thank you for the enlightening interview. i look forward to your response.
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